Of clinical importance, FlaB-treated DCs isolated from the PB of patients with HDM-sensitive asthma were able to drive the generation of CD4+Foxp3+ Treg cells upon co-culture with autologous CD4+ T cells in the presence of HDM extracts, a process mediated by IL-10 release in cell culture supernatants [89]. The gene discussed is IL10; the disease is asthma.