Altogether, these data confirm that HMG-CoA reductase inhibitors favorably affect cardiac remodeling after myocardial infarction and, for the first time, show that the improved myocardial response upon ischemic/necrotic insult by statins also encompasses a boost in resident CSC activation, ensuing in significantly higher new myocyte formation. Here, HMGCR is linked to myocardial infarction.