Research on SLC6A4 AluJb methylation in MDD and amygdala reactivity, in addition to its associations with 5HTTLPR-rs25531 and stress, in depressed patients revealed that individuals with low methylation, in conjunction with a shorter MDD history and lower amygdala reactivity, may present an epigenetic process more adaptable to stress [13,14,28,51]. The gene discussed is SLC6A4; the disease is major depressive disorder.