FBXW7, a novel E3 ubiquitin ligase, was identified as the major regulator of CRY2-mediated chemosensitivity, which promotes ubiquitin-mediated degradation of CRY2 leading to downregulation of CRY2 and increased CRC cell response to oxaliplatin [46]. Here, FBXW7 is linked to colorectal carcinoma.