Importantly, reduced expression of FBXW7 was found to correlate with high CRY2 expression in CRC tissue samples and with poor survival, which clearly underlines the importance of FBXW7-CRY2 axis in CRC chemoresistance and puts forward CRY2 as a novel target to counteract chemoresistance in CRC. Here, FBXW7 is linked to colorectal carcinoma.