Indeed, an overexpression of PER3 potentiates the effects of chemotherapy in colorectal CSCs in vitro and reduces their clonogenic and self-renewal capacity concomitant with the inhibition of cancer stem cell-related signaling pathways including Notch-1 and β-catenin, which reduces the chemoresistance and self-renewal capability of colorectal CSCs [49]. The gene discussed is PER3; the disease is cancer.