Thus, an overexpression of BMAL1 in tongue squamous cell carcinoma cells was shown to increase cytotoxic effects of paclitaxel in vitro and in vivo, and its expression levels in tumor tissues from tongue squamous cell carcinoma patients positively correlated with paclitaxel efficiency, which indicates tumor suppressor role of BMAL1 [55]. The gene discussed is BMAL1; the disease is tongue squamous cell carcinoma.