Compared to those who had the lowest (1st quartile) p16INK4a mRNA expression, those with highest (4th quartile) p16INK4a mRNA expression had 2.46-fold increased risk of breast cancer (OR = 2.46; 95%CI: 1.57, 4.04; p < 0.001). Here, CDKN2A is linked to breast carcinoma.