In the multivariate analysis, higher p16INK4a mRNA expression was marginally associated with 1.28-fold increased risk of breast cancer (OR = 1.28; 95%CI: 0.98, 2.97; p = 0.053) after adjusting age, BMI category, smoking status, alcohol status, and physical activity. The gene discussed is CDKN2A; the disease is breast carcinoma.