The involvement of TLR-2 receptors in the response of cells stimulated with components of Gram-positive cells was also reported by Xie et al., which demonstrated the increase of invasiveness and adhesiveness of breast cancer cells upon bacterial peptidoglycan addition by the NF-ĸB-STAT3-Smad3 signaling pathway [82]. This evidence concerns the gene SMAD3 and breast carcinoma.