Future studies, besides elucidating precise intracellular mechanisms and signaling pathways involved, might unveil if mGluRI-ErbB crosstalk varies among diverse brain areas/cellular populations, whether it is instrumental to proper cognitive functions and complex behaviors and, ultimately, if such ErbB-dependent regulation of mGluRI is disrupted in pathological conditions or ErbB targeting can be exploited to develop novel strategies for the treatment of brain disorders. The gene discussed is EGFR; the disease is brain disorder.