TP53 and coronary artery disorder: To prove the role of protein p53 in the development of other inflammatory diseases, Kolovou et al. (2018) evaluated the relationship between gene polymorphism of p53 and ischemic heart disease in his study, and Chang et al. (2013) suggested a link between post-translational modification of p53 and ERK5 proteins detected during endothelial apoptosis and inflammation which contributes to the formation of atherosclerotic plaque [24,38].