CREB1 and liver cancer: Finally, we recruited 354 Asian liver cancer patients (including hepatitis B virus HBV and hepatitis C virus HCV) for large-scale analysis of the mitochondrial genes CREB, MCU, MICU1, and MICU2, and used immunohistochemistry (IHC) and bioinformatics techniques to analyze their clinical characteristics to predict the prognosis of HCC.