The expression of all the four mitochondrial proteins was significantly higher with higher IHC scores in the tumor tissues than in the normal liver tissues (median IHC score of CREB: 158.3 vs. 90.0, p < 0.001; MCU: 27.1 vs. 0.2, p < 0.001; MICU1: 139.4 vs. 97.8, p < 0.001; MICU2: 49.0 vs. 9.2, p < 0.001; Figure 3B). Here, CREB1 is linked to neoplasm.