For example, CREB is overexpressed in hematopoietic tumors such as acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), Hodgkin’s lymphoma, chronic lymphatic leukemia (CLL), as well as solid tumors such as melanoma, renal cell, ovarian, prostate, lung, gastric, esophageal, pancreatic, and breast carcinoma, brain tumors and HCC [20]. This evidence concerns the gene CREB1 and brain neoplasm.