Finally, we recruited 354 Asian liver cancer patients (including hepatitis B virus HBV and hepatitis C virus HCV) for large-scale analysis of the mitochondrial genes CREB, MCU, MICU1, and MICU2, and used immunohistochemistry (IHC) and bioinformatics techniques to analyze their clinical characteristics to predict the prognosis of HCC. This evidence concerns the gene MICU1 and hepatocellular carcinoma.