Its interaction with major histocompatibility complex type II (MHC II) causes CD8+ T-cell exhaustion in synchrony with PD-1 receptor in B-cell non-Hodgkin’s lymphoma [74,75], extranodal NK/T-cell lymphoma [76], Hodgkin’s lymphoma (HL) [77], and malignant Hodgkin Reed-Sternberg (HRS) [77]. This evidence concerns the gene CD8A and Hodgkins lymphoma.