Some biomarkers found in the peripheral blood, with promising roles in the early diagnosis of PC, are the methylation status of ADAMTS1 (A disintegrin and metalloproteinase with thrombospondin motifs 1) and BNC1 (zinc finger protein basonuclin-1) cell-free deoxyribonucleic acid (DNA) [5]. Here, ADAMTS1 is linked to pachyonychia congenita.