Similarly, antibody-mediated deletion of GPVI or treatment of mice with recombinant SDF-1-GPVI reduced inflammation and infarct size demonstrating a pivotal role of GPVI in ischemia reperfusion injury following ligation of the left anterior descending artery (LAD) in a mouse model of myocardial infarction [56,63]. This evidence concerns the gene CXCL12 and myocardial infarction.