SDF-1α-CXCR4 localized to lipid rafts in the platelet membrane trigger platelet reactivity [110], while decreased surface expression of CXCR4 in patients with inherited thrombocytopenia corroborates with impaired CXCL12/SDF1α-triggered platelet aggregation [111]. The gene discussed is CXCR4; the disease is inherited thrombocytopenia.