One hypothesis is that miR-196a and/or miR-125b-5p, here found enriched in Ngfr−/− SC EVs, could potentially play a role in the observed diabetic phenotype in mice lacking SC p75NTR expression as they were recently associated with type 1 diabetes [43] and in the regulation of body fat distribution [63]. This evidence concerns the gene NGFR and type 1 diabetes mellitus.