Loss of JNK1 in hematopoietic cells rescues macrophages from apoptosis and promotes early atherosclerosis [74], whereas scavenger receptor class B type I (SCARB1) is a critical mediator of macrophage efferocytosis via the proto-oncogene tyrosine-protein kinase (Src)/phosphoinositide 3-kinase (PI3K)/Ras-related C3 botulinum toxin substrate 1 (Rac1) pathway in atherosclerosis. The gene discussed is RAC1; the disease is atherosclerosis.