In addition, mutations in p53 family members, TERT promoter, ATM, RB1, MEN1, NF1, NF2, SWI/SNF, mismatch repair genes, and histone methyltransferase have been associated with tumor de-differentiation process and tumor progression [202,203,204,205,206,207,208,209,210]. The gene discussed is TP53; the disease is neoplasm.