Yang et al. [99] found that in a rabbit model of atherosclerosis based on a high-fat diet combined with aorta balloon injury, treatment with ruxolitinib substantially reduced the area of atherosclerotic plaques and inhibited production of pro-inflammatory cytokines IL-6, IL-1β, IFN-γ (interferon gamma), and TNF-α (tumour necrosis factor alpha). This evidence concerns the gene IFNG and atherosclerosis.