In an orthotopic murine model of hepatocellular carcinoma, the Hippo-Yes-associated protein (YAP) signaling pathway induced by CAFs in cancer cells increases EMT and stimulates actin cytoskeleton polymerization via the upregulation of Rho-GTPase activating proteins (ARHGAP29), both effects resulting in promotion of invasion and metastasis in cancer cells [106]. The gene discussed is YAP1; the disease is cancer.