TAGLN and colorectal neoplasm: In human colorectal tumors, two other sub-populations of CAFs were reported based on their transcriptome, CAF-A, rich in MMP2, αFAP and COL1A2 (type 1 collagen α−chain 2) mRNA, and CAF-B, rich in α-SMA, PDGF-A and TAGLN (transgelin) mRNA, but their function was not determined [60].