In recent years, several new therapies for treatment of hemophilia—both factor- and non-factor-based—have received marketing authorization, while more are undergoing clinical trials [30,31] In novel factor products, so-called extended half-life (EHL) products, plasma half-life was prolonged up to 1.5-fold for FVIII and 2.4–4.8-fold for FIX by modification of recombinant FVIII and FIX proteins [32]. This evidence concerns the gene F8 and hemophilia.