PTGS2 and cancer: REM sleep loss also affected several genes such as prostaglandin-endoperoxide synthase (Ptgs2), B-cell lymphoma 2 (Bcl-2), Proto-Oncogene, Tyrosine Kinase receptor (Kit), KRAS Proto-Oncogene (K-Ras), and Fos Proto-Oncogene (Fos), which are marked in cancer pathways (Figure S3).