We therefore undertook the present study to investigate the efficacy of a new combination of these four elements, SOD 10mg daily, ALA 570 mg daily, ALC 300mg daily, and B12 250mcg daily, contained in one tablet, in DN in patients with DMT2, and generalized neuropathy (both DPN and DCAN) who have received metformin for at least four years. This evidence concerns the gene SOD1 and liver dysplastic nodule.