However, despite the clear anti-inflammatory effect of SM on the leukocyte count in carrageenan-induced peritonitis, this compound did not affect the level of pro-inflammatory cytokines in peritoneal exudates in comparison with the untreated carrageenan-challenged mice (Figure 9C), which agreed well with the effects of SM on the production of IL-6 and TNF-α, as revealed in the LPS-induced endotoxemia model (Figure 8A,B). The gene discussed is TNF; the disease is peritonitis.