Similarly, in pancreatic ductal adenocarcinoma, macrophages that phagocytose apoptotic cells secrete the 14-3-3 zeta/delta (14-3-3ζ) protein, which inhibits apoptosis through 14-3-3ζ/Axl pathway, leading to phosphorylation of Akt and activation of cellular pro-survival mechanisms in the tumor cells [239]. This evidence concerns the gene AKT1 and neoplasm.