It has reported that g_Bacteroides;s_acidifaciens may have potential for treating metabolic diseases such as diabetes and obesity [32], and g_Parabacteroides; s_distasonis attenuated toll-like receptor 4 signaling and Akt activation to block inflammation and colon tumor formation in the mice fed with HFD-azoxymethane diet [33]. This evidence concerns the gene TLR4 and obesity due to melanocortin 4 receptor deficiency.