It is also essential to consider that increased ROS has been recognized to control the actions of other signaling pathways implicated in tumor growth and programmed cell death, such as the phosphoinositide 3-kinase/protein kinase B (PI3K/PKB) and mitogen-activated protein kinase (MAPK) signaling pathways, through the oxidation of negative feedback loop controllers [77,78,79]. The gene discussed is AKT1; the disease is neoplasm.