A possible hypothesis regarding these results is that CALR-mutated MPN subjects require greater amounts of IFNa to attain an analogous molecular response [91], as confirmed by Czech et al., who reported higher doses of IFN were needed to achieve the same response in CALR mutant 32D cells than in JAK2V617F mutant 32D cells [90]. Here, CALR is linked to myeloproliferative disorder.