PROS1 and viral infectious disease: Actin microfilaments in particular have been associated with the rounding and loss of adhesion that frequently occur with viral infection or transformation in response to secondary metabolites [51,52], with the intracellular transport of viral structural proteins and viral particles [53], with the budding process of many enveloped viruses [54], and with the assembly of virions in the cytoplasm [55] and in the nucleus [56].