LIMK1 and Parkinson disease: In turn, a study using a mouse PD model showed that baicalein, through the upregulation of gene expression (mainly glutamate receptor, GLR, alpha-synuclein, SNCA, and LIM domain kinase 1, LIMK1) promoted not only neurogenesis, but also neurotrophin pathway signaling, neuroblast proliferation, and motor and behavioral improvement [64].