In contrast, in the PD rat model, resveratrol (20 mg/kg) inhibited cerebral CASP3 activity, while downregulating the expression of the glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) genes, resulting in a reduction in endoplasmic reticulum stress-induced apoptosis [113]. The gene discussed is DDIT3; the disease is Parkinson disease.