VHL and cancer: However, the Chi-squared test χ2 revealed, after exclusion of gender-specific cancer diseases, five different genetic mutations that are significantly more common in men than in women: CDKN2A (p = 0.04), CTNNB1 (p = 0.002), KIT (p = 0.0005), SLX4 (p = 0.034), and VHL (p = 0.046).