We determined whether CAFs from luminal tumors presented phenotypic variability at their basal expression of several genes implicated in tumor progression (S100A4, FGF2, FGF7, HGF, PDGFA, PDGFB, TGFβ, VEGFA, IGF2, IL6, IL8, CCL2, CXCL12, uPA, MMP2, MMP9, MMP11, NFκB, and TIMP1). This evidence concerns the gene IGF2 and neoplasm.