Interestingly, when we analyzed the TLR4 expression in CD4+CD25+ cells, we observed a 4.5-fold higher frequency in PAC patients, compared with HD (MD 12.3%, IQR 3–49 vs. MD 2.7%, IQR 1.8–1.4, respectively; p = 0.0042) (Table 2). The gene discussed is CD4; the disease is gonorrhea.