Rg3 inhibited the protein expression of VEGF in human hepatocellular (HepG2) [38], esophageal (Eca-109) and renal cell carcinoma (786-0) cell lines [39], decreased VEGF-A and -C in anaplastic thyroid and papillary thyroid cancer cell lines [40] and decreased transcripts of VEGF-A, -B and -C in a mouse model of breast cancer [25]. The gene discussed is VEGFA; the disease is hereditary clear cell renal cell carcinoma.