Similarly, transfection of GPR65 in human lymphoma cells (U937) decreases the expression of the oncogene c-Myc and their proliferative activity, and contrary effects occur when GPR65 is knockdown [162,163], and in vivo, these GPR65-transfected U937 cells showed a reduced tumorigenic and metastatic potential when xenografted in severe combined immunodeficient mice (SCID) mice [163]. This evidence concerns the gene GPR65 and lymphoma.