These recent evidences together with the facts that SUCNR1 is expressed in significant stromal components such endothelial cells and fibroblasts, where it mediates angiogenic and fibrogenic responses [196,197], and that SUCNR1 expression can be up-regulated by the accumulation of succinate in the tumor environment, make likely that this signaling pathway would significantly affect the cancerous process. Here, SUCNR1 is linked to neoplasm.