GPR68 and Familial prostate cancer: In this sense, genetically induced overexpression of GPR68 in metastatic human prostate cancer cells (PC3) reduced the metastasis after their orthotopic transplantation in nude mice [176] while, in vitro, transfection of GPR68 to breast cancer cells reduced their migratory ability [177] and the induction of this receptor by lenalidomide in myelodysplastic syndrome cells mediated the pro-apoptotic effect of this antineoplastic agent [178].