FACT binds the MIE enhancer/promoter during latent infection, and shRNA-mediated suppression of SPT16 or treatment with curaxins to inhibit FACT leads to decreased UL123 expression when induced with TNFα to stimulate reactivation [192], suggesting FACT aids in transactivation of this locus in response to reactivation cues. Here, SUPT16H is linked to disease arising from reactivation of latent virus.