In the Rapid Emergency Department Heart failure Outpatient Trial (REDHOT) study that included patients presenting to the emergency department with dyspnea, there was a large disconnect between the perceived severity of HF status (i.e., the New York Heart Association functional class) by emergency physicians and BNP levels, and a lower BNP level portend a favorable prognosis [21]. The gene discussed is NPPB; the disease is hydrops fetalis.