NNT and central nervous system cancer: In addition, down-regulating NNT-AS1 in glioma cells can up-regulate e-cadherin and decrease the levels of n-cadherin and vimentin, which could be rescued by the miR494-3p inhibitor or protein arginine methyltransferase 1 (PRMT1) overexpression, suggesting that NNT-AS1 may increase the EMT of tumors through the miR-494-3p/PRMT1 axis [31].