NNT-AS1 may activate the Wnt signaling pathway, the ERK signaling pathway, the PI3K/ AKT signaling pathway, and the MAPK/Slug signaling pathway, etc. Many studies have shown that NNT-AS1 dysregulation is related to tumor prognosis, especially in breast cancer and CRC, in which the abnormal expression level of NNT-AS1 is an independent prognostic marker. This evidence concerns the gene MAPK1 and breast cancer.