Our previous studies reported that topical treatment of rhEGF relieved S. aureus-induced inflammation and AD-like skin lesions in Nc/Nga mice, and rhEGF treatment attenuated P. acne-induced inflammatory responses, at least in part, through the modulation of TLR2 signaling in human epidermal keratinocytes [18,20]. Here, TLR2 is linked to Alzheimer disease.