CD80 and periventricular leukomalacia: Previous studies suggest microglia within PVL have a predominantly pro-inflammatory immune reactive phenotype, associated with the expression of the major histocompatibility complex class II (MHC-II) and co-stimulatory molecule B7-2 (CD80) [10], while microglia within DSCL have a phagocytic phenotype associated with the abundance of CD68+ amoeboid microglia [11,12].