Quantitative assessment of the intra- and inter-tissue relationships revealed that the magnitude of CD27-positive cells within ILS/ELS gives a wide-ranged distribution: in NT, from 52.04% to 89.98% (median 77.34%); in CRC, from 28.57% to 95.68% (median 73.05%), and in CRCLM, from 38.75% to 89.38% (median 68.33%). Here, CD27 is linked to colorectal carcinoma.