The anatomy- and composition-based variables (n = 24) thereby included “ILS/ELS count”, “ILS/ELS size (mm2)”, “ILS/ELS density (cells/mm2)”, “GC size of ILS/ELS size (%)” (NT and CRC), “ILS to ILS distance (mm)” (NT), “CD20+ cells in ILS/ELS (%)”, “AID+ ILS/ELS count”, “Ki67+ cells in ILS/ELS (%)” and “CD27+ cells in ILS/ELS (%)” (Table S1). Here, AICDA is linked to colorectal carcinoma.