Islet amyloid polypeptide (IAPP) formed by islets of the pancreas can cause inflammasome NLR family pyrin domain containing 3 (NLRP3) in macrophages and dendritic cells to release IL-1β via its receptor on β-cells, which can signal cell death, impaired insulin secretory ability, and T2D. Here, INS is linked to type 2 diabetes mellitus.