SOD1 and amyotrophic lateral sclerosis: One important finding of Keren-Shaul and colleagues is that DAM microglia appears to be a cell population not associated exclusively with AD; in fact, the authors identify the DAM signature also in microglia isolated from the spinal cord of SOD1.G93A mouse model of ALS both in the early and in the late stages of the disease (Table 1c) [56].