TARDBP and amyotrophic lateral sclerosis: This represents a neuropathological hallmark of ALS, as well as other neurodegenerative diseases, e.g., several types of inclusions have been reported in neuronal perikaryon and neurites, such as phosphorylated neurofilaments in ALS, ubiquitinated skein-like and Lewy-body like inclusions in ALS and PD, transactive response DNA binding protein 43KDa (TDP-43) in ALS and FTD; tau-positive neurofibrillary tangles in AD.