To counteract an undersupply of oxygen and the related limitations for further cell proliferation, a vascularization of the tumor mass is triggered by the secretion of various pro-angiogenic factors including vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), interleukin-8 and fibroblast growth factor-2 [11]. The gene discussed is VEGFA; the disease is neoplasm.