Furthermore, the authors were able to demonstrate a miRNA-519-mediated enhanced invasiveness and tumor growth in a subcutaneous xenograft tumor experiment as well as an interaction with programmed death-ligand 1 (PD-L1) in PDAC cell lines Panc1 and SW1990, which regulated the PD-L1 expression and induced cancer cell apoptosis [45]. This evidence concerns the gene CD274 and cancer.