TP53 and cancer: Then, we performed the mRNA expression analysis of the P53 gene (alias TP53, Tumor Protein 53) which responds to various cellular stresses by regulating expression of many target genes, and is involved in modulation of processes such as cell cycle arrest, apoptosis, senescence, DNA repair, changes in metabolism; P53 is a transcription factor with a key role in genetic stability and therefore crucially interfering with cancer formation [29].