The DE miRNAs (miR-1246, miR-200, miR-223, miR-29b, and miR-145) reported earlier in sepsis patients, for example, contribute to regulation of signaling molecules (IKKα, MAL, TRAF6, MyD88) in the TLR-4 pathway during LPS exposure [23,24]. The gene discussed is MAL; the disease is Sepsis.