The miR-223, one of the most widely studied miRNAs, positively regulates the proliferation and differentiation of neutrophils, and directly regulates IL-6, chemokines (CXCL2, CCL3) and inflammatory cell recruitment [28], and has already been recognized as a specific and sensitive diagnostic biomarker of sepsis in humans [29,30]. This evidence concerns the gene CXCL2 and Sepsis.