Thus, RA is currently treated with a wide variety of therapeutic drugs ranging from steroidal/nonsteroidal anti-inflammatory drugs (NSAID), glucocorticoids (GCs), and disease-modifying anti-rheumatic drugs (DMARDs) of synthetic origin, such as conventional synthetic DMARDs (e.g., methotrexate), biological, and biosimilar DMARDs (e.g., TNF inhibitors or IL-6 inhibitors), as well as targeted synthetic DMARDs (the Janus kinase (JAK) inhibitors) targeting specific immune cells, cytokines, or pro-inflammatory pathways [2,26,39]. This evidence concerns the gene IL6 and rheumatoid arthritis.