Pro-EGCG such as octaacetate [31] or peracetate-protected EGCG suppressed xenograft tumor growth, inhibited tumor angiogenesis, and reduced the expression of vascular endothelial growth factor A (VEGFA) and HIF1α by the PI3K/AKT/mTOR signaling pathway [38]. This evidence concerns the gene HIF1A and neoplasm.