The high propensity of CF patients to develop intestinal blockade, manifesting as meconium ileus in newborns and distal intestinal obstruction syndrome in adults, illustrates the key role of CFTR in intestinal electrolyte and fluid homeostasis and identifies this channel, or components of its activation mechanism, as suitable targets for antidiarrhoeal drug therapy [39, 40]. The gene discussed is CFTR; the disease is Meconium ileus.