INS and obesity due to melanocortin 4 receptor deficiency: By 30 weeks, high fat‐fed SM/J mice increase circulating insulin levels 5.3‐fold and pancreatic insulin levels 1.9‐fold, in line with other models of hyperinsulinemic nondiabetic‐obesity (Fransson et al., 2013; Gupta et al., 2017; Liu, Jetton, & Leahy, 2002).