INS and obesity due to melanocortin 4 receptor deficiency: In conjunction with changing β‐cell morphology, diabetic‐obesity is associated with altered β‐cell function, including diminished first phase insulin secretion, increased basal insulin secretion, and decreased β‐cell insulin production (Cheng et al., 2013; Deng et al., 2004; Marchetti et al., 2004; Peyot et al., 2010).