BRCA2 and neoplasm: Based on these guidelines, individuals may meet criteria based on their tumour pathology (negative status for oestrogen receptor, progesterone receptor and ERBB2/HER2 expression), or where a BRCA1 and BRCA2 pathogenic variant probability of 10% or more is calculated using a validated pathogenic variant prediction tool, such as the BOADICEA assessment programme [10].