p120ctn is a tumor suppressor gene that is down-regulated or lost in a vast array of epithelial cancers, including NSCLC, head and neck squamous cell carcinoma (HNSCC), esophageal and colon cancers, and is associated with advanced stage, metastasis and poor patient prognosis [12–30]. Here, CTNND1 is linked to head and neck squamous cell carcinoma.