Further deepening the importance of understanding the role of interferon in COVID-19 is a new study showing that the presence of auto-antibodies against either or both of interferon alpha (IFNɑ) and interferon omega (IFNω) were rare in healthy, asymptomatic, or mild SARS-CoV-2 infection, but over-represented among patients with life-threatening COVID-19 pneumonia [82]. The gene discussed is IFNA1; the disease is COVID-19.