Because our immunostaining results showed that colonic cells do not co-stain for SSTR1 and GLP-2R (Fig 3G–3J), indicating that these cells represent different NEC types, we first screened different CRC cell lines (n = 5) and characterized them in terms of proportion of ALDEFLUOR+, SSTR1+ and GLP-2R+ cells. This evidence concerns the gene SSTR1 and colorectal carcinoma.